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TB-BIOCHIP
(Registration certificate NФС 032б2004/0889-04) The "TB-BIOCHIP" developed in the Engelhardt Institute of Molecular Biology are able to detect over 95% of TB-strains resistant to rifampin and above 80% of those resistant to isosniazid, which are the most effective anti-TB drugs available today. The analysis requires less than one day, and it provides exact data on the type of mutation responsible for the drug-resistance. The benefits of the "TB-BIOCHIP"-based diagnostics
The benefit value of application of biochips appears to be higher that 25000 roubles per one patient with drug-resistant TB form. "TB-BIOCHIP"-based analysis
Reports in the specialized ImageWare computer program
At present, 'TB-Biochips' have been introduced in the medical practice of 12 anti-TB Centers in Russia. They have also been tested in the South Korea, Kirgizia and they are currently under evaluation in two clinical laboratories of the USA. |
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Tuberculosis Micobacteria tuberculosis is the causative agent of
the disease.
 ( x3000 )
In case of an active form of TB, micobacteria are quickly multiplied in the lungs or other tissues resulting in severe intoxication of the organism.
Facts
According to the World Health Organization , 10 mln "new"TB patients are registered annually
in the world, and above 3 million people die from this disease.
In 1995 the WHO declared TB a global emergency.
Strains that are resistant to multidrug treatments afflict on average from 2 to 30 percent of victims, and they are particularly dangerous.
In 2004, TB caused death of nearly 85% among all victims of infectious and parasitic diseases in Russia.
TB in Russia: Morbidity data (per 100.000 people)
TB in different regions of the Russian Federation (per 100.000 people)
Vocabulary
DNA - desoxyribonucleic acid - carrier of genetic information in living cells.
Biochip - a matrix of microscopic gel pads arranged on glass or other support. Each pad can operate as a miniature test tube. M. tuberculosis - TB causative agent Rifampin, isoniazid - most common anti-Tb drugs routinely prescribed to all primary patients. TB MDR (tuberculosis with multiple drug-resistance) - the form of disease when TB micobacteria in the body of a patient are not sensitive to the first line (most commonly used) anti-TB drugs. PCR - polymerase chain reaction allows to obtain gene copies in unrestricted numbers. Hybridization method allows to identify the tested DNA by reaction between the latter and the molecular probes immobilized on the chip. |
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